1280x1024 is native on most 19" flat screens, and that's what I'm used to looking at most often now.
My notebook is actually 1400x1050 with an ultrasharp screen.
I like the screen real estate, though my eyes are getting old, so I do use the "large fonts" setting so text is slightly oversized.
When designing, I still recommend designing for 800x600 though because even if a user has higher resolution, most people do not surf with their browser windows maximized.
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