EVERY legal casino in the states has a vested interest in preventing the spread of online gaming, since one day it will come to pass that they have licenses to do it legally with US citizens.
The biggest obstacles I think at this point to it are splitting up the taxes amongst the various states that will be participating -- and figuring out how much they will tax -- and then creating an environment where people aren't allowed to use credit cards -- only debit products -- to gamble with; this is something that could be easily done by BIN number filtering and shouldn't be a problem.
The one problem that will come up is cardholders who live in states where gambling is illegal but hold cards from states where it is allowed... that does pose a few issues with the BIN system but AVS match should work... perhaps Lee can revisit her zip code list and sell it to the casinos